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Article

CDKN2A/p16 Loss Implicates CDK4 as a Therapeutic Target in Imatinib-Resistant Dermatofibrosarcoma Protuberans.

Molecular cancer therapeutics - 1 Jun 2015

Eilers Grant, Czaplinski Jeffrey T, Mayeda Mark, Bahri Nacef, Tao Derrick, Zhu Meijun, Hornick Jason L, Lindeman Neal I, Sicinska Ewa, Wagner Andrew J, Fletcher Jonathan A, Mariño-Enriquez Adrian

Abstract excerpt

Dermatofibrosarcoma protuberans (DFSP) is an aggressive PDGFB-dependent cutaneous sarcoma characterized by infiltrative growth and frequent local recurrences. Some DFSP progress to a higher-grade fibrosarcomatous form, with rapid growth and increased risk of metastasis. Imatinib provides clinical benefit in approximately 50% of patients with unresectable or metastatic DFSP. However, efficacious medical therapies...

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Identifiers

PMID: 25852058
DOI: 10.1158/1535-7163.MCT-14-0793
PMCID: PMC4458458

Genes

CDK4
PDGFB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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