Evolution of Dermatofibrosarcoma Protuberans to DFSP-Derived Fibrosarcoma: An Event Marked by Epithelial-Mesenchymal Transition-like Process and 22q Loss.

doi:10.1158/1541-7786.MCR-16-0068

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Evolution of Dermatofibrosarcoma Protuberans to DFSP-Derived Fibrosarcoma: An Event Marked by Epithelial-Mesenchymal Transition-like Process and 22q Loss.

Molecular cancer research : MCR - 1 Sept 2016

Stacchiotti Silvia, Astolfi Annalisa, Gronchi Alessandro, Fontana Andrea, Pantaleo Maria A, Negri Tiziana, Brenca Monica, Tazzari Marcella, Urbini Milena, Indio Valentina, Colombo Chiara, Radaelli Stefano, Brich Silvia, Dei Tos Angelo P, Casali Paolo G, Castelli Chiara, Dagrada Gian Paolo, Pilotti Silvana, Maestro Roberta

Abstract excerpt

UNLABELLED: Dermatofibrosarcoma protuberans (DFSP) is a rare and indolent cutaneous sarcoma. At times, a fibrosarcomatous transformation marked by a more aggressive clinical behavior may be present. We investigated the natural history and the molecular bases of progression from classic DFSP to the fibrosarcomatous form (FS-DFSP), looking, retrospectively, at the outcome of all patients affected by primary DFSP...

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PMID: 27256159
DOI: 10.1158/1541-7786.MCR-16-0068

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