Article
Preclinical evaluation of potential therapeutic targets in dedifferentiated liposarcoma.
Oncotarget - 23 Aug 2016
Hanes Robert, Grad Iwona, Lorenz Susanne, Stratford Eva W, Munthe Else, Reddy Chilamakuri Chandra Sekhar, Meza-Zepeda Leonardo A, Myklebost Ola
Abstract excerpt
Sarcomas are rare cancers with limited treatment options. Patients are generally treated by chemotherapy and/or radiotherapy in combination with surgery, and would benefit from new personalized approaches. In this study we demonstrate the potential of combining personal genomic characterization of patient tumors to identify targetable mutations with in vitro testing of specific drugs in patient-derived cell...
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