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Article

The p53 regulatory gene <i>MDM2</i> is a direct transcriptional target of MYCN in neuroblastoma

11 Jan 2005

Abstract excerpt

The MYCN oncogene is the major negative prognostic marker in neuroblastoma with important roles in both the pathogenesis and clinical behavior of this aggressive malignancy. MYC oncogenes activate both proliferative and apoptotic cellular pathways and, accordingly, inhibition of p53-mediated apoptosis is a prerequisite for MYC-driven tumorigenesis. To identify novel transcriptional targets mediating the...

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PMID: 15644444
DOI: 10.1073/pnas.0405495102

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The p53 regulatory gene <i>MDM2</i> is a direct transcriptional target of MYCN in neuroblastomaPMID 15644444Read ↗

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Dissection of the oncogenic MYCN transcriptional network reveals a large set of clinically relevant cell cycle genes as drivers of neuroblastoma tumorigenesisSemantic proximity Read ↗

MYCN sensitizes neuroblastoma to the MDM2-p53 antagonists Nutlin-3 and MI-63.Semantic proximity Read ↗

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Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomasSemantic proximity Read ↗

The N-myc Oncogene: Maximizing its Targets, Regulation, and Therapeutic PotentialSemantic proximity Read ↗

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