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Article

The c-Rel subunit of NF-κB is a crucial regulator of phenotype and motility of HaCaT keratinocytes.

Archives of dermatological research - 1 Aug 2015

Lorenz Verena Natalie, Schön Michael P, Seitz Cornelia S

Abstract excerpt

The transcription factor NF-κB exerts key functions in epidermal homeostasis and carcinogenesis. Its c-Rel subunit is expressed in squamous cell carcinoma, and c-Rel down-regulation results in increased apoptosis, G2/M cell cycle delay with reduced proliferation and aberrant mitotic spindle formation. To further study the impact of c-Rel on essential keratinocyte features such as migration and epithelial...

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PMID: 25842167
DOI: 10.1007/s00403-015-1562-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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