Article
Cyclic supplementation of 5-MTHF is effective for the correction of hyperhomocysteinemia.
Nutrition research (New York, N.Y.) - 1 Jun 2015
Ambrosino Pasquale, Lupoli Roberta, Di Minno Alessandro, Nardo Assunta, Marrone Emiliana, Lupoli Valentina, Scaravilli Alessandra, Mitidieri Emma, Tufano Antonella, Di Minno Matteo Nicola Dario
Abstract excerpt
Folic acid supplementation is the mainstay treatment of hyperhomocysteinemia (HHcy). However, no recommendations are currently available in regard to the optimal replacement therapy. Therefore, this prospective study hypothesized that a cyclic schedule (1 month of therapy followed by 2 months of withdrawal) of 5-methyltetrahydrofolate (5-MTHF) would reduce plasma levels of fasting total homocysteine (tHcy) in...
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