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TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer

25 May 2020

Abstract excerpt

IL-22 has dual functions during tumorigenesis. Short term IL-22 production protects against genotoxic stress, whereas uncontrolled IL-22 activity promotes tumor growth; therefore, tight regulation of IL-22 is essential. TGF-β1 promotes the differentiation of Th17 cells, which are known to be a major source of IL-22, but the effect of TGF-β signaling on the production of IL-22 in CD4+ T cells is controversial....

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PMID: 32451418
DOI: 10.1038/s41467-020-16363-w

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