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Isolation ofMycobacterium lepromatosisand Development of Molecular Diagnostic Assays to DistinguishMycobacterium lepraeandM. lepromatosis

12 Nov 2019

Abstract excerpt

BACKGROUND: Mycobacterium leprae was thought to be the exclusive causative agent of leprosy until Mycobacterium lepromatosis was identified in a rare form of leprosy known as diffuse lepromatous leprosy (DLL). METHODS: We isolated M. lepromatosis from a patient with DLL and propagated it in athymic nude mouse footpads. Genomic analysis of this strain (NHDP-385) identified a unique repetitive element, RLPM, on...

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PMID: 31732729
DOI: 10.1093/cid/ciz1121

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