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Article

Effects of ALDH2 genotype, PPI treatment and L-cysteine on carcinogenic acetaldehyde in gastric juice and saliva after intragastric alcohol administration.

PloS one - 1 Jan 2015

Maejima Ryuhei, Iijima Katsunori, Kaihovaara Pertti, Hatta Waku, Koike Tomoyuki, Imatani Akira, Shimosegawa Tooru, Salaspuro Mikko

Abstract excerpt

Acetaldehyde (ACH) associated with alcoholic beverages is Group 1 carcinogen to humans (IARC/WHO). Aldehyde dehydrogenase (ALDH2), a major ACH eliminating enzyme, is genetically deficient in 30-50% of Eastern Asians. In alcohol drinkers, ALDH2-deficiency is a well-known risk factor for upper aerodigestive tract cancers, i.e., head and neck cancer and esophageal cancer. However, there is only a limited evidence...

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Source

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Identifiers

PMID: 25831092
DOI: 10.1371/journal.pone.0120397
PMCID: PMC4382225

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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