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Article

Deficient aldehyde dehydrogenase 2 is associated with increased risk for esophageal squamous cell carcinoma in the presence of gastric hypochlorhydria.

Scandinavian journal of gastroenterology - 1 Nov 2010

Oikawa Tomoyuki, Iijima Katsunori, Koike Tomoyuki, Uno Kaname, Horii Toru, Iwai Wataru, Abe Yasuhiko, Asano Naoki, Imatani Akira, Shimosegawa Tooru

Abstract excerpt

OBJECTIVE: In Orientals, deficient aldehyde dehydrogenase 2 (ALDH2) is associated with an increased risk for esophageal squamous cell carcinoma (ESCC). The local metabolism of carcinogenic acetaldehyde in the upper gastrointestinal tract could be involved in the association, but the underlying mechanism has not been fully elucidated. Since an anacidic stomach can promote bacteria-catalyzed local acetaldehyde...

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Share to Aldehyde Dehydrogenase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Squamous Cell

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Share to Endoscopy, Gastrointestinal

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Source

Identifiers

PMID: 20521872
DOI: 10.3109/00365521.2010.495419

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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