Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ALDH2 genotype has no effect on salivary acetaldehyde without the presence of ethanol in the systemic circulation.

PloS one - 1 Jan 2013

Helminen Andreas, Väkeväinen Satu, Salaspuro Mikko

Abstract excerpt

BACKGROUND: Acetaldehyde associated with alcoholic beverages was recently classified as carcinogenic (Group 1) to humans based on uniform epidemiological and biochemical evidence. ALDH2 (aldehyde dehydrogenase 2) deficient alcohol consumers are exposed to high concentrations of salivary acetaldehyde and have an increased risk of upper digestive tract cancer. However, this interaction is not seen among ALDH2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetaldehyde
Share to Aldehyde Dehydrogenase
Share to Aldehyde Dehydrogenase, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoresis, Agar Gel

Share to Environmental Exposure

Share to Ethanol

Share to Saliva

Share to Surveys and Questionnaires

Source

Open in PubMed Open full text

Identifiers

PMID: 24058561
DOI: 10.1371/journal.pone.0074418
PMCID: PMC3772811

Genes

ALDH2
IMPACT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ALDH2 genotype has no effect on salivary acetaldehyde without the presence of ethanol in the systemic circulation.PMID 24058561Read ↗

Effects of ALDH2 genotype, PPI treatment and L-cysteine on carcinogenic acetaldehyde in gastric juice and saliva after intragastric alcohol administration.Semantic proximity Read ↗

Salivary acetaldehyde concentration according to alcoholic beverage consumed and aldehyde dehydrogenase-2 genotype.Semantic proximity Read ↗

Local Acetaldehyde—An Essential Role in Alcohol-Related Upper Gastrointestinal Tract CarcinogenesisSemantic proximity Read ↗

[Commentary] ACETALDEHYDE: A CUMULATIVE CARCINOGEN IN HUMANSSemantic proximity Read ↗

Genetic-epidemiological evidence for the role of acetaldehyde in cancers related to alcohol drinking.Semantic proximity Read ↗

Alcohol consumption and cancer of the gastrointestinal tract.Semantic proximity Read ↗

ALDH2-deficiency as genetic epidemiologic and biochemical model for the carcinogenicity of acetaldehydeSemantic proximity Read ↗

Increased cancer risk in heavy drinkers with the alcohol dehydrogenase 1C*1 allele, possibly due to salivary acetaldehyde.Semantic proximity Read ↗

Acetaldehyde, Microbes, and Cancer of the Digestive TractSemantic proximity Read ↗

Oral cancer and polymorphism of ethanol metabolising genes.Semantic proximity Read ↗

Genetic polymorphisms of alcohol and aldehyde dehydrogenases and risk for esophageal and head and neck cancers.Semantic proximity Read ↗

Interactions of alcohol and tobacco in gastrointestinal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.