Article
Increased expression of forkhead box M1 is associated with aggressive phenotype and poor prognosis in estrogen receptor-positive breast cancer.
Journal of Korean medical science - 1 Apr 2015
Ahn Hyein, Sim Jongmin, Abdul Rehman, Chung Min Sung, Paik Seung Sam, Oh Young-Ha, Park Chan Kum, Jang Kiseok
Abstract excerpt
Fox transcription factors play a critical role in the regulation of a variety of biological processes. While FoxM1 behaves like the oncogenic transcription factor, FoxO3a is known as a tumor suppressor by inhibiting FoxM1. This study aimed to investigate the clinicopathological significance of FoxM1 and FoxO3a expression in breast cancer. Expression of FoxM1 and FoxO3a were analyzed by immunohistochemical...
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