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Article

Selective and genetic constraints on pneumococcal serotype switching.

PLoS genetics - 1 Mar 2015

Croucher Nicholas J, Kagedan Lisa, Thompson Claudette M, Parkhill Julian, Bentley Stephen D, Finkelstein Jonathan A, Lipsitch Marc, Hanage William P

Abstract excerpt

Streptococcus pneumoniae isolates typically express one of over 90 immunologically distinguishable polysaccharide capsules (serotypes), which can be classified into "serogroups" based on cross-reactivity with certain antibodies. Pneumococci can alter their serotype through recombinations affecting the capsule polysaccharide synthesis (cps) locus. Twenty such "serotype switching" events were fully characterised...

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Identifiers

PMID: 25826208
DOI: 10.1371/journal.pgen.1005095
PMCID: PMC4380333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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