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Article

Functional conservation of Gsdma cluster genes specifically duplicated in the mouse genome.

G3 (Bethesda, Md.) - 3 Oct 2013

Tanaka Shigekazu, Mizushina Youichi, Kato Yoriko, Tamura Masaru, Shiroishi Toshihiko

Abstract excerpt

Mouse Gasdermin A3 (Gsdma3) is the causative gene for dominant skin mutations exhibiting alopecia. Mouse has two other Gsdma3-related genes, Gsdma and Gsdma2, whereas human and rat have only one related gene. To date, no skin mutation has been reported for human GSDMA and rat Gsdma as well as mouse Gsdma and Gsdma2. Therefore, it is possible that only Gsdma3 has gain-of-function type mutations to cause dominant...

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Identifiers

PMID: 23979942
DOI: 10.1534/g3.113.007393
PMCID: PMC3789809

Genes

GSDMA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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