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Article

Impaired autophagy promotes hair loss in the C3H/HeJ mouse model of alopecia areata

2 Jun 2022

Abstract excerpt

Alopecia areata (AA) involves an aberrant immune attack on the hair follicle (HF), which leads to hair loss. Previous genetic data from our lab pointed to a connection between macroautophagy/autophagy and AA pathogenesis, and GWAS identified STX17, CLEC16A and BCL2L11/BIM as risk factors for AA. Additionally, AA patients have copy number deletions in region spanning the ATG4B gene. To test whether autophagy might...

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PMID: 35652954
DOI: 10.1080/15548627.2022.2074104

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