Toll-like receptor 1 N248S polymorphism affects T helper 1 cytokine production and is associated with serum immunoglobulin E levels in Taiwanese allergic patients.

doi:10.1016/j.jmii.2015.01.004

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Article

Toll-like receptor 1 N248S polymorphism affects T helper 1 cytokine production and is associated with serum immunoglobulin E levels in Taiwanese allergic patients.

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi - 1 Feb 2017

Yang Chin-An, Chiang Bor-Luen

Abstract excerpt

BACKGROUND/PURPOSE: This study was carried out to investigate whether toll-like receptor-1 (TLR1) rs4833095 (N248S) variant, common in the Taiwanese population, contributes to pathogenesis of allergy. METHODS: TLR2/1 ligand Pam3CSK4-stimulated cytokine production in peripheral blood mononuclear cells and monocyte-derived dendritic cells of different genotypes were measured via enzyme-linked immunosorbent assay....

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PMID: 25825356
DOI: 10.1016/j.jmii.2015.01.004

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TLR1
TLR2

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