Article
Late-onset increases in oxidative stress and other tumorigenic activities and tumors with a Ha-ras mutation in the liver of adult male C3H mice gestationally exposed to arsenic.
Toxicological sciences : an official journal of the Society of Toxicology - 1 Oct 2012
Nohara Keiko, Tateishi Yukiyo, Suzuki Takehiro, Okamura Kazuyuki, Murai Hikari, Takumi Shota, Maekawa Fumihiko, Nishimura Noriko, Kobori Masuko, Ito Takaaki
Abstract excerpt
Tumorigenesis is a complex process involving genetic, epigenetic, and metabolic alterations. Gestational arsenic exposure has been shown to increase hepatic tumors in adult male offspring of C3H mice, which spontaneously develop hepatic tumors often harboring activating Ha-ras mutation. We explor...
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