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DNA polymerase-catalyzed incorporation of nucleotides modified with a G-quadruplex-derived DNAzyme.

Chemical communications (Cambridge, England) - 30 Apr 2015

Verga D, Welter M, Steck A-L, Marx A

Abstract excerpt

We show that nucleotides which are modified with a G-quadruplex-derived DNAzyme are substrates for DNA polymerases. Based on this finding we developed a naked-eye detection system that allows the detection of single nucleotide variations in DNA.

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PMID: 25825211
DOI: 10.1039/c5cc01387a

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