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Article

Deficiency of angulin-2/ILDR1, a tricellular tight junction-associated membrane protein, causes deafness with cochlear hair cell degeneration in mice.

PloS one - 1 Jan 2015

Higashi Tomohito, Katsuno Tatsuya, Kitajiri Shin-Ichiro, Furuse Mikio

Abstract excerpt

Tricellular tight junctions seal the extracellular spaces of tricellular contacts, where the vertices of three epithelial cells meet, and are required for the establishment of a strong barrier function of the epithelial cellular sheet. Angulins and tricellulin are known as specific protein components of tricellular tight junctions, where angulins recruit tricellulin. Mutations in the genes encoding...

Read the complete abstract on PubMed

Topics

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Share to Deafness
Share to Epithelial Cells
Share to Hair Cells, Auditory

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hearing

Share to Membrane Proteins

Share to Organ of Corti

Share to Receptors, Cell Surface

Share to Tight Junctions

Source

Open in PubMed Open full text

Identifiers

PMID: 25822906
DOI: 10.1371/journal.pone.0120674
PMCID: PMC4378975

Genes

ILDR1
LSR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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