Article
MYD88 L265P and CXCR4 mutations in lymphoplasmacytic lymphoma identify cases with high disease activity.
British journal of haematology - 1 Jun 2015
Schmidt Janine, Federmann Birgit, Schindler Natalie, Steinhilber Julia, Bonzheim Irina, Fend Falko, Quintanilla-Martinez Leticia
Abstract excerpt
Recurrent mutations in MYD88 have been identified in >90% of lymphoplasmacytic lymphoma (LPL). Recently, WHIM (warts, hypogammaglobulinaemia, infections, myelokathexis) syndrome-like mutations in CXCR4 have been described in 28% of LPL cases, and seem to impact clinical presentation and response to therapy. We investigated the presence of the MYD88 L265P mutation in 90 decalcified, formalin-fixed,...
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