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Article

Clone-specific MYD88 L265P and CXCR4 mutation status can provide clinical utility in suspected Waldenström macroglobulinemia/lymphoplasmacytic lymphoma.

Leukemia research - 1 Dec 2016

Burnworth Bettina, Wang Zhixing, Singleton Timothy P, Bennington Angela, Fritschle Wayne, Bennington Richard, Brodersen Lisa Eidenschink, Wells Denise A, Loken Michael R, Zehentner Barbara K

Abstract excerpt

MYD88 L265P, a diagnostic marker for lymphoplasmacytic lymphoma (LPL)/Waldenström macroglobulinemia (WM) can also be detected in other hematopoietic malignancies. We demonstrate a novel approach to increase the specificity of this marker for WM/LPL diagnosis by combining flow cytometric cell sorting with molecular analysis. Clonal B-lymphocyte and co-occurring clonal plasma cell populations of low-grade B-cell...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27890075
DOI: 10.1016/j.leukres.2016.10.008

Genes

MYD88
CXCR4
LPL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Clone-specific MYD88 L265P and CXCR4 mutation status can provide clinical utility in suspected Waldenström macroglobulinemia/lymphoplasmacytic lymphoma.PMID 27890075Read ↗

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Significances of MYD88L265P and CXCR4WHIM Mutations in Waldenstrom Macroglobulinemia.Semantic proximity Read ↗

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<i>MYD88</i>mutant lymphoplasmacytic lymphoma/Waldenström macroglobulinemia has distinct clinical and pathological features as compared to its mutation negative counterpartSemantic proximity Read ↗

Lymphoplasmacytic Lymphoma With a Non-IgM Paraprotein Shows Clinical and Pathologic Heterogeneity and May Harbor MYD88 L265P Mutations.Semantic proximity Read ↗

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