Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A phosphorylation-related variant ADD1-rs4963 modifies the risk of colorectal cancer.

PloS one - 1 Jan 2015

Shen Na, Liu Cheng, Li Jiaoyuan, Chen Xueqin, Yang Yang, Zhu Ying, Gong Yajie, Gong Jing, Zhong Rong, Cheng Liming, Miao Xiaoping

Abstract excerpt

It is well-established that abnormal protein phosphorylation could play an essential role in tumorgenesis by disrupting a variety of physiological processes such as cell growth, signal transduction and cell motility. Moreover, increasing numbers of phosphorylation-related variants have been identified in association with cancers. ADD1 (α-adducin), a versatile protein expressed ubiquitously in eukaryotes, exerts...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asian People
Share to Calmodulin-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Colorectal Neoplasms

Share to Genetic Association Studies

Share to Mutation, Missense

Share to Phosphorylation

Source

Open in PubMed Open full text

Identifiers

PMID: 25816007
DOI: 10.1371/journal.pone.0121485
PMCID: PMC4376805

Genes

ADD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A phosphorylation-related variant ADD1-rs4963 modifies the risk of colorectal cancer.PMID 25816007Read ↗

[A missense SNP in the codon of ADD1 phosphorylation site associated with non-cardia gastric cancer susceptibility in a Chinese population].Semantic proximity Read ↗

Correlation Between CASC8, SMAD7 Polymorphisms and the Susceptibility to Colorectal Cancer: An Updated Meta-Analysis Based on GWAS Results.Semantic proximity Read ↗

SMAD7 rs4939827 variant contributes to colorectal cancer risk in Chinese population.Semantic proximity Read ↗

Pin1 promoter rs2233678 and rs2233679 polymorphisms in cancer: a meta-analysis.Semantic proximity Read ↗

SMAD7 gene polymorphisms and their influence on patients with colorectal cancer.Semantic proximity Read ↗

Genome-wide association study identifies a new SMAD7 risk variant associated with colorectal cancer risk in East Asians.Semantic proximity Read ↗

Variation rs9929218 and risk of the colorectal Cancer and adenomas: A meta-analysis.Semantic proximity Read ↗

Phosphorylation states of cell cycle and DNA repair proteins can be altered by the nsSNPs.Semantic proximity Read ↗

A common SMAD7 variant is associated with risk of colorectal cancer: evidence from a case-control study and a meta-analysis.Semantic proximity Read ↗

The -842G/C polymorphisms of PIN1 contributes to cancer risk: a meta-analysis of 10 case-control studies.Semantic proximity Read ↗

The Pin1 gene polymorphism and the susceptibility of oral squamous cell carcinoma in East China.Semantic proximity Read ↗

The rs2233678 polymorphism in PIN1 promoter region reduced cancer risk: a meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.