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Article

An Improved Reverse Genetics System to Overcome Cell-Type-Dependent Ebola Virus Genome Plasticity.

The Journal of infectious diseases - 1 Oct 2015

Tsuda Yoshimi, Hoenen Thomas, Banadyga Logan, Weisend Carla, Ricklefs Stacy M, Porcella Stephen F, Ebihara Hideki

Abstract excerpt

Reverse genetics systems represent a key technique for studying replication and pathogenesis of viruses, including Ebola virus (EBOV). During the rescue of recombinant EBOV from Vero cells, a high frequency of mutations was observed throughout the genomes of rescued viruses, including at the RNA editing site of the glycoprotein gene. The influence that such genomic instability could have on downstream uses of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25810440
DOI: 10.1093/infdis/jiu681
PMCID: PMC4564527

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