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Article

ClpP-independent function of ClpX interferes with telithromycin resistance conferred by Msr(A) in Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 1 Jan 2015

Vimberg Vladimir, Lenart Jakub, Janata Jiri, Balikova Novotna Gabriela

Abstract excerpt

The ABCF family protein Msr(A) confers high resistance to macrolides but only low resistance to ketolides in staphylococci. Mutations in conserved functional regions of ClpX as well as deletion of clpX significantly increased Msr(A)-mediated resistance to the ketolide antibiotic telithromycin. ClpX is the chaperone component of the ClpXP two-component proteolytic system. Nevertheless, no changes in resistance...

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Identifiers

PMID: 25801573
DOI: 10.1128/AAC.04367-14
PMCID: PMC4432155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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