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Treating diet-induced diabetes and obesity with human embryonic stem cell-derived pancreatic progenitor cells and antidiabetic drugs.

Stem cell reports - 14 Apr 2015

Bruin Jennifer E, Saber Nelly, Braun Natalie, Fox Jessica K, Mojibian Majid, Asadi Ali, Drohan Campbell, O'Dwyer Shannon, Rosman-Balzer Diana S, Swiss Victoria A, Rezania Alireza, Kieffer Timothy J

Abstract excerpt

Human embryonic stem cell (hESC)-derived pancreatic progenitor cells effectively reverse hyperglycemia in rodent models of type 1 diabetes, but their capacity to treat type 2 diabetes has not been reported. An immunodeficient model of type 2 diabetes was generated by high-fat diet (HFD) feeding in SCID-beige mice. Exposure to HFDs did not impact the maturation of macroencapsulated pancreatic progenitor cells...

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Identifiers

PMID: 25801507
DOI: 10.1016/j.stemcr.2015.02.011
PMCID: PMC4400611

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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