Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A LINE-1 insertion in DLX6 is responsible for cleft palate and mandibular abnormalities in a canine model of Pierre Robin sequence.

PLoS genetics - 1 Apr 2014

Wolf Zena T, Leslie Elizabeth J, Arzi Boaz, Jayashankar Kartika, Karmi Nili, Jia Zhonglin, Rowland Douglas J, Young Amy, Safra Noa, Sliskovic Saundra, Murray Jeffrey C, Wade Claire M, Bannasch Danika L

Abstract excerpt

Cleft palate (CP) is one of the most commonly occurring craniofacial birth defects in humans. In order to study cleft palate in a naturally occurring model system, we utilized the Nova Scotia Duck Tolling Retriever (NSDTR) dog breed. Micro-computed tomography analysis of CP NSDTR craniofacial structures revealed that these dogs exhibit defects similar to those observed in a recognizable subgroup of humans with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cleft Palate
Share to Dogs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Homeobox

Share to Homeodomain Proteins

Share to Long Interspersed Nucleotide Elements

Share to Mandible

Share to Mutation, Missense

Share to Pierre Robin Syndrome

Source

Open in PubMed Open full text

Identifiers

PMID: 24699068
DOI: 10.1371/journal.pgen.1004257
PMCID: PMC3974639

Genes

DLX6
DLX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A LINE-1 insertion in DLX6 is responsible for cleft palate and mandibular abnormalities in a canine model of Pierre Robin sequence.PMID 24699068Read ↗

Genome-wide association studies in dogs and humans identify ADAMTS20 as a risk variant for cleft lip and palate.Semantic proximity Read ↗

DLX4is associated with orofacial clefting and abnormal jaw developmentSemantic proximity Read ↗

A Splice Acceptor Variant in DLL3 Is Associated with Spondylocostal Dysostosis in a Litter of Mixed-Breed Dogs.Semantic proximity Read ↗

Association of the Disheveled 2 (DVL2) Gene c.2044delC Variant with Increased Risk of Canine Cleft Palate.Semantic proximity Read ↗

A Nonsense Mutation in the PRKG2 Gene in Dalmatian Dogs with ChondrodysplasiaSemantic proximity Read ↗

<i>FGF4</i> retrogene on CFA12 is responsible for chondrodystrophy and intervertebral disc disease in dogsSemantic proximity Read ↗

A genotype-first approach identifies variants for orofacial clefts and other phenotypes in dogsSemantic proximity Read ↗

Complex disease and phenotype mapping in the domestic dog.Semantic proximity Read ↗

Non-Syndromic Cleft Palate and Transverse Limb Deficiency Segregating in a Family of DogsSemantic proximity Read ↗

A naturally occurring canine model of syndromic congenital microphthalmia.Semantic proximity Read ↗

FGF4 retrogene on CFA12 is responsible for chondrodystrophy and intervertebral disc disease in dogs.Semantic proximity Read ↗

Comparison of village dog and wolf genomes highlights the pivotal role of the neural crest in dog domesticationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.