Article
Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open angle glaucoma.
PLoS genetics - 1 Feb 2011
Kuchtey John, Olson Lana M, Rinkoski Tommy, Mackay Edward O, Iverson T M, Gelatt Kirk N, Haines Jonathan L, Kuchtey Rachel W
Abstract excerpt
Primary open angle glaucoma (POAG) is a leading cause of blindness worldwide, with elevated intraocular pressure as an important risk factor. Increased resistance to outflow of aqueous humor through the trabecular meshwork causes elevated intraocular pressure, but the specific mechanisms are unknown. In this study, we used genome-wide SNP arrays to map the disease gene in a colony of Beagle dogs with inherited...
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