Article
Alpha tryptase allele of Tryptase 1 (TPSAB1) gene associated with Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) in Vietnam and Philippines.
Human immunology - 1 May 2015
Velasquez Clara Vasquez, Roman Arthur Dessi, Lan Nguyen Thi Phuong, Huy Nguyen Tien, Mercado Edelwisa Segubre, Espino Fe Esperanza, Perez Ma Lucila M, Huong Vu Thi Que, Thuy Tran Thi, Tham Vo Dinh, Nga Cao Thi Phi, Ha Tran Thi Ngoc, Bilar Josie M, Bajaro Jemimah Dawn P, Baello Benilda Q, Kikuchi Mihoko, Yasunami Michio, Morita Kouichi, Watanabe Naohiro, Karbwang Juntra, Hirayama Kenji
Abstract excerpt
We previously reported, significantly higher levels of Chymase and Tryptase in early stage plasma of DSS patients prior to the occurrence of shock suggesting a possible role of mast cells in dengue pathogenesis. To further investigate, we analyzed CMA1 promoter SNP (rs1800875) and TPSAB1 gene alleles, which encode the Human Chymase and α- and β- tryptase 1 enzymes respectively, for susceptibility to Dengue...
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