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Article

Structural basis for the neutralization of hepatitis E virus by a cross-genotype antibody.

Cell research - 1 May 2015

Gu Ying, Tang Xuhua, Zhang Xiao, Song Cuiling, Zheng Minghua, Wang Kaihang, Zhang Jun, Ng Mun-Hon, Hew Choy-Leong, Li Shaowei, Xia Ningshao, Sivaraman J

Abstract excerpt

Hepatitis E virus (HEV), a non-enveloped, positive-sense, single-stranded RNA virus, is a major cause of enteric hepatitis. Classified into the family Hepeviridae, HEV comprises four genotypes (genotypes 1-4), which belong to a single serotype. We describe a monoclonal antibody (mAb), 8G12, which equally recognizes all four genotypes of HEV, with ∼ 2.53-3.45 nM binding affinity. The mAb 8G12 has a protective,...

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Identifiers

PMID: 25793314
DOI: 10.1038/cr.2015.34
PMCID: PMC4423075

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