Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparison of methods in the detection of ALK and ROS1 rearrangements in lung cancer.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Apr 2015

Rogers Toni-Maree, Russell Prudence A, Wright Gavin, Wainer Zoe, Pang Jia-Min, Henricksen Leigh A, Singh Shalini, Stanislaw Stacey, Grille James, Roberts Esteban, Solomon Benjamin, Fox Stephen B

Abstract excerpt

INTRODUCTION: The use of targeted therapies toward specific oncogenic driver mutations has become a critical factor in the treatment of patients with lung cancer. It is therefore essential to utilize tests with high performance characteristics. Fluorescence in situ hybridization (FISH) is the standard method for detecting anaplastic lymphoma kinase (ALK) and ROS1 rearrangements in non-small-cell lung cancer but...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anaplastic Lymphoma Kinase
Share to Carcinoma, Non-Small-Cell Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement

Share to Immunohistochemistry

Share to In Situ Hybridization, Fluorescence

Share to Protein-Tyrosine Kinases

Share to Proto-Oncogene Proteins

Share to Receptor Protein-Tyrosine Kinases

Source

Identifiers

PMID: 25789833
DOI: 10.1097/JTO.0000000000000465

Genes

ROS1
ALK
CISH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparison of methods in the detection of ALK and ROS1 rearrangements in lung cancer.PMID 25789833Read ↗

Concordance of Immunohistochemistry and Fluorescence In Situ Hybridization in the Detection of Anaplastic Lymphoma Kinase (ALK) and Ros Proto-oncogene 1 (ROS1) Gene Rearrangements in Non-Small Cell Lung Carcinoma: A 4.5-Year Experience Highlighting Challenges and Pitfalls.Semantic proximity Read ↗

Detection of ROS1 rearrangement in non-small cell lung cancer: current and future perspectivesSemantic proximity Read ↗

ROS1 immunohistochemistry among major genotypes of non-small-cell lung cancer.Semantic proximity Read ↗

Testing for ROS1 in non-small cell lung cancer: a review with recommendationsSemantic proximity Read ↗

Molecular diagnosis in non-small-cell lung cancer: expert opinion on ALK and ROS1 testingSemantic proximity Read ↗

ALK and ROS1 testing on lung cancer cytologic samples: Perspectives.Semantic proximity Read ↗

Analysis of receptor tyrosine kinase ROS1-positive tumors in non-small cell lung cancer: identification of a FIG-ROS1 fusion.Semantic proximity Read ↗

Fluorescence In Situ Hybridization and Immunohistochemistry as Diagnostic Methods for ALK Positive Non-Small Cell Lung Cancer PatientsSemantic proximity Read ↗

Screening for <i><scp>ROS</scp>1</i> gene rearrangements in non‐small‐cell lung cancers using immunohistochemistry with <scp>FISH</scp> confirmation is an effective method to identify this rare targetSemantic proximity Read ↗

Next-generation Sequencing for ALK and ROS1 Rearrangement Detection in Patients With Non–small-cell Lung Cancer: Implications of FISH-positive PatternsSemantic proximity Read ↗

IHC versus FISH versus NGS to detect ALK gene rearrangement in NSCLC: all questions answered?Semantic proximity Read ↗

Detection of ROS1 Gene Rearrangement in Lung Adenocarcinoma: Comparison of IHC, FISH and Real-Time RT-PCRSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.