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Molecular diagnosis in non-small-cell lung cancer: expert opinion on ALK and ROS1 testing

19 Apr 2021

Abstract excerpt

The effectiveness of targeted therapies with tyrosine kinase inhibitors in non-small-cell lung cancer (NSCLC) depends on the accurate determination of the genomic status of the tumour. For this reason, molecular analyses to detect genetic rearrangements in some genes (ie, ALK , ROS1 , RET and NTRK ) have become standard in patients with advanced disease. Since immunohistochemistry is easier to implement and...

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PMID: 33875457
DOI: 10.1136/jclinpath-2021-207490

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