Article
Strategies for individual phenotyping of linoleic and arachidonic acid metabolism using an oral glucose tolerance test.
PloS one - 1 Jan 2015
Saccenti Edoardo, van Duynhoven John, Jacobs Doris M, Smilde Age K, Hoefsloot Huub C J
Abstract excerpt
The ability to restore homeostasis upon environmental challenges has been proposed as a measure for health. Metabolic profiling of plasma samples during the challenge response phase should offer a profound view on the flexibility of a phenotype to cope with daily stressors. Current data modeling approaches, however, struggle to extract biological descriptors from time-resolved metabolite profiles that are able to...
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