Article
The factor VIII D1241E polymorphism is associated with decreased factor VIII activity and not with activated protein C resistance levels.
Thrombosis and haemostasis - 1 Mar 2005
Scanavini Daniela, Legnani Cristina, Lunghi Barbara, Mingozzi Federico, Palareti Gualtiero, Bernardi Francesco
Abstract excerpt
Elevated factor VIII (FVIII) levels are a recognized risk factor for venous thrombosis. Recently, family studies suggested that the G allele of the 3951C/G (D1241E) FVIII polymorphism is associated to lower FVIII activity. We investigated in case-control studies both biological effects (FVIII levels and activated protein C sensitivity ratio) and clinical associations (venous thromboembolism) of the D1241E change....
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