Article
A common polymorphism decreases LRP1 mRNA stability and is associated with increased plasma factor VIII levels.
Biochimica et biophysica acta. Molecular basis of disease - 1 Jun 2017
Lee Jiann-Der, Hsiao Kuang-Ming, Chang Pey-Jium, Chen Chih-Cheng, Kuo Ya-Wen, Huang Yen-Chu, Hsu Huan-Lin, Lin Ya-Hui, Wu Chih-Ying, Huang Ying-Chih, Lee Meng, Hsu Chia-Yu, Pan Yi-Ting, Kuo Chih-Yu, Lin Chun-Hsien
Abstract excerpt
The low-density lipoprotein receptor-related protein 1 (LRP1) gene is associated with increased levels of plasma factor VIII (FVIII). We aimed to explore eight functional genetic LRP1 variants for their potential roles in regulating FVIII levels and acute ischemic stroke (AIS). This genetic association study enrolled 192 patients with AIS and 134 controls. There were no significant differences in the genetic...
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