Article
Should HLA mismatch acceptability for sensitized transplant candidates be determined at the high-resolution rather than the antigen level?
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Apr 2015
Duquesnoy R J, Kamoun M, Baxter-Lowe L A, Woodle E S, Bray R A, Claas F H J, Eckels D D, Friedewald J J, Fuggle S V, Gebel H M, Gerlach J A, Fung J J, Middleton D, Nickerson P, Shapiro R, Tambur A R, Taylor C J, Tinckam K, Zeevi A
Abstract excerpt
Defining HLA mismatch acceptability of organ transplant donors for sensitized recipients has traditionally been based on serologically defined HLA antigens. Now, however, it is well accepted that HLA antibodies specifically recognize a wide range of epitopes present on HLA antigens and that molecularly defined high resolution alleles corresponding to the same low resolution antigen can possess different epitope...
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