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MGMT Expression Predicts PARP-Mediated Resistance to Temozolomide

16 Mar 2015

Abstract excerpt

Melanoma and other solid cancers are frequently resistant to chemotherapies based on DNA alkylating agents such as dacarbazine and temozolomide. As a consequence, clinical responses are generally poor. Such resistance is partly due to the ability of cancer cells to use a variety of DNA repair enzymes to maintain cell viability. Particularly, the expression of MGMT has been linked to temozolomide resistance, but...

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PMID: 25777962
DOI: 10.1158/1535-7163.mct-14-0810

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