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MGMT inhibition regulates radioresponse in GBM, GSC, and melanoma

29 May 2024

Abstract excerpt

Radiotherapy is the standard treatment for glioblastoma (GBM), but the overall survival rate for radiotherapy treated GBM patients is poor. The use of adjuvant and concomitant temozolomide (TMZ) improves the outcome; however, the effectiveness of this treatment varies according to MGMT levels. Herein, we evaluated whether MGMT expression affected the radioresponse of human GBM, GBM stem-like cells (GSCs), and...

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PMID: 38811596
DOI: 10.1038/s41598-024-61240-x

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