Article
Direct and indirect consequences on gene expression of a thyroid hormone receptor alpha 1 mutation restricted to Sertoli cells.
Molecular reproduction and development - 1 Dec 2014
Chatonnet Fabrice, Livera Gabriel, Fumel Betty, FouchÉCourt Sophie, Flamant Frédéric
Abstract excerpt
Thyroid hormone is required for the timely transition of Sertoli cells from proliferative to differentiating and maturing. This transition takes place during a critical developmental period in mammals, which in mice is the first post-natal week. In order to identify the underlying molecular mechanisms of this differentiation process, we used Cre/loxP technology to selectively block the function of the thyroid...
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