Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis.

Genes & development - 15 Jan 2006

Rao Manjeet K, Pham John, Imam J Saadi, MacLean James A, Murali Deepa, Furuta Yasuhide, Sinha-Hikim Amiya P, Wilkinson Miles F

Abstract excerpt

Using a novel tissue-specific RNA interference (RNAi) approach that mimics the principle by which naturally occurring microRNAs (miRNA) are made, we demonstrate that the Wilms' tumor 1 (WT1) transcription factor has an essential role in spermatogenesis. Mice depleted of WT1 in Sertoli nurse cells suffered from increased germ cell apoptosis, loss of adherens junctions, disregulation of adherence...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adherens Junctions
Share to DNA Polymerase II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gonads

Share to Ribonuclease III

Share to RNA Precursors

Share to Sertoli Cells

Share to Spermatogenesis

Share to WT1 Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 16418481
DOI: 10.1101/gad1367806
PMCID: PMC1356106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis.PMID 16418481Read ↗

The Wilms Tumor Gene, Wt1, Is Critical for Mouse Spermatogenesis via Regulation of Sertoli Cell Polarity and Is Associated with Non-Obstructive Azoospermia in HumansSemantic proximity Read ↗

The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis.Semantic proximity Read ↗

<i>Wt1</i> deficiency causes undifferentiated spermatogonia accumulation and meiotic progression disruption in neonatal miceSemantic proximity Read ↗

Reprogramming of Sertoli cells to fetal-like Leydig cells by <i>Wt1</i> ablationSemantic proximity Read ↗

A Wt1-Dmrt1 Transgene Restores DMRT1 to Sertoli Cells of Dmrt1−/− Testes: A Novel Model of DMRT1-Deficient Germ Cells1Semantic proximity Read ↗

Wt1 negatively regulates beta-catenin signaling during testis development.Semantic proximity Read ↗

WT-1 is required for early kidney development.Semantic proximity Read ↗

Nephropathy and defective spermatogenesis in mice transgenic for a single isoform of the Wilms' tumour suppressor protein, WT1-KTS, together with one disrupted Wt1 allele.Semantic proximity Read ↗

Influence of Wilms' tumor suppressor gene WT1 on bovine Sertoli cells polarity and tight junctions via non-canonical WNT signaling pathwaySemantic proximity Read ↗

DAZAP1, an hnRNP protein, is required for normal growth and spermatogenesis in mice.Semantic proximity Read ↗

Claudin 11 deficiency in mice results in loss of the Sertoli cell epithelial phenotype in the testis.Semantic proximity Read ↗

The functions of Wt1 in mouse gonad development and somatic cells differentiationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.