Article
APOA5 variants predispose hyperlipidemic patients to atherogenic dyslipidemia and subclinical atherosclerosis.
Atherosclerosis - 1 May 2015
Guardiola Montse, Cofán Montserrat, de Castro-Oros Isabel, Cenarro Ana, Plana Núria, Talmud Philippa J, Masana Lluís, Ros Emilio, Civeira Fernando, Ribalta Josep
Abstract excerpt
BACKGROUND: Triglycerides (TG) are the initiators of the metabolic changes leading to the atherogenic dyslipidemia, which is a major inducer of atherosclerosis as a result of quantitative and qualitative changes in lipoprotein subclass distributions. We hypothesized that variation at the of APOA5 gene locus, encoding apoAV, a key regulator of TG levels, significantly affect lipoprotein subclass distributions...
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