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Article

Amyloid precursor protein enhances Nav1.6 sodium channel cell surface expression.

The Journal of biological chemistry - 8 May 2015

Liu Chao, Tan Francis Chee Kuan, Xiao Zhi-Cheng, Dawe Gavin S

Abstract excerpt

Amyloid precursor protein (APP) is commonly associated with Alzheimer disease, but its physiological function remains unknown. Nav1.6 is a key determinant of neuronal excitability in vivo. Because mouse models of gain of function and loss of function of APP and Nav1.6 share some similar phenotypes, we hypothesized that APP might be a candidate molecule for sodium channel modulation. Here we report that APP...

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Source

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Identifiers

PMID: 25767117
DOI: 10.1074/jbc.M114.617092
PMCID: PMC4424341

Genes

APP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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