Article
Predicting functional and regulatory divergence of a drug resistance transporter gene in the human malaria parasite.
BMC genomics - 22 Feb 2015
Siwo Geoffrey H, Tan Asako, Button-Simons Katrina A, Samarakoon Upeka, Checkley Lisa A, Pinapati Richard S, Ferdig Michael T
Abstract excerpt
BACKGROUND: The paradigm of resistance evolution to chemotherapeutic agents is that a key coding mutation in a specific gene drives resistance to a particular drug. In the case of resistance to the anti-malarial drug chloroquine (CQ), a specific mutation in the transporter pfcrt is associated with resistance. Here, we apply a series of analytical steps to gene expression data from our lab and leverage 3...
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