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Article

A genetic predisposition score associates with reduced aerobic capacity in response to acute normobaric hypoxia in lowlanders.

High altitude medicine & biology - 1 Mar 2015

Masschelein Evi, Puype Joke, Broos Siacia, Van Thienen Ruud, Deldicque Louise, Lambrechts Diether, Hespel Peter, Thomis Martine

Abstract excerpt

Given the high inter-individual variability in the sensitivity to high altitude, we hypothesize the presence of underlying genetic factors. The aim of this study was to construct a genetic predisposition score based on previously identified high-altitude gene variants to explain the inter-individual variation in the reduced maximal O2 uptake (ΔVo2max) in response to acute hypoxia. Ninety-six healthy young male...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25761120
DOI: 10.1089/ham.2014.1083

Genes

ADRB2
ACE
EPAS1
PPARA
VEGFA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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