Article
Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults.
Obesity reviews : an official journal of the International Association for the Study of Obesity - 1 Apr 2015
Zimmermann E, Ängquist L H, Mirza S S, Zhao J H, Chasman D I, Fischer K, Qi Q, Smith A V, Thinggaard M, Jarczok M N, Nalls M A, Trompet S, Timpson N J, Schmidt B, Jackson A U, Lyytikäinen L P, Verweij N, Mueller-Nurasyid M, Vikström M, Marques-Vidal P, Wong A, Meidtner K, Middelberg R P, Strawbridge R J, Christiansen L, Kyvik K O, Hamsten A, Jääskeläinen T, Tjønneland A, Eriksson J G, Whitfield J B, Boeing H, Hardy R, Vollenweider P, Leander K, Peters A, van der Harst P, Kumari M, Lehtimäki T, Meirhaeghe A, Tuomilehto J, Jöckel K-H, Ben-Shlomo Y, Sattar N, Baumeister S E, Smith G Davey, Casas J P, Houston D K, März W, Christensen K, Gudnason V, Hu F B, Metspalu A, Ridker P M, Wareham N J, Loos R J F, Tiemeier H, Sonestedt E, Sørensen T I A
Abstract excerpt
Previously, a single nucleotide polymorphism (SNP), rs9939609, in the FTO gene showed a much stronger association with all-cause mortality than expected from its association with body mass index (BMI), body fat mass index (FMI) and waist circumference (WC). This finding implies that the SNP has s...
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