Article
Detailed analysis of variants in FTO in association with body composition in a cohort of 70-year-olds suggests a weakened effect among elderly.
PloS one - 1 Jan 2011
Jacobsson Josefin A, Almén Markus Sällman, Benedict Christian, Hedberg Lilia A, Michaëlsson Karl, Brooks Samantha, Kullberg Joel, Axelsson Tomas, Johansson Lars, Ahlström Håkan, Fredriksson Robert, Lind Lars, Schiöth Helgi B
Abstract excerpt
BACKGROUND: The rs9939609 single-nucleotide polymorphism (SNP) in the fat mass and obesity (FTO) gene has previously been associated with higher BMI levels in children and young adults. In contrast, this association was not found in elderly men. BMI is a measure of overweight in relation to the individuals' height, but offers no insight into the regional body fat composition or distribution. OBJECTIVE: To examine...
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