Article
Gene expression of FTO in human subcutaneous adipose tissue, peripheral blood mononuclear cells and adipocyte cell line.
Journal of nutrigenetics and nutrigenomics - 1 Jan 2010
Lappalainen Tiina, Kolehmainen Marjukka, Schwab Ursula, Pulkkinen Leena, de Mello Vanessa D F, Vaittinen Maija, Laaksonen David E, Poutanen Kaisa, Uusitupa Matti, Gylling Helena
Abstract excerpt
BACKGROUND/AIMS: The common polymorphism rs9939609 of the fat mass and obesity-associated gene (FTO) is strongly associated with obesity, but the biological function is still unknown. We compared the FTO gene expression in subcutaneous adipose tissue and peripheral blood mononuclear cells (PBMCs) between overweight and normal weight individuals. We also investigated if mRNA levels of FTO in adipose tissue...
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