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Article

Human endogenous retrovirus envelope proteins target dendritic cells to suppress T-cell activation.

European journal of immunology - 1 Jun 2015

Hummel Jonas, Kämmerer Ulrike, Müller Nora, Avota Elita, Schneider-Schaulies Sibylle

Abstract excerpt

Though mostly defective, human endogenous retroviruses (HERV) can retain open reading frames, which are especially expressed in the placenta. There, the envelope (env) proteins of HERV-W (Syncytin-1), HERV-FRD (Syncytin-2), and HERV-K (HML-2) were implicated in tolerance against the semi-allogenic fetus. Here, we show that the known HERV env-binding receptors ASCT-1 and -2 and MFSD2 are expressed by DCs and...

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Source

Identifiers

PMID: 25752285
DOI: 10.1002/eji.201445366

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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