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Article

Autophagy-independent senescence and genome instability driven by targeted telomere dysfunction.

Autophagy - 1 Jan 2015

Mar Florie A, Debnath Jayanta, Stohr Bradley A

Abstract excerpt

Telomere dysfunction plays a complex role in tumorigenesis. While dysfunctional telomeres can block the proliferation of incipient cancer clones by inducing replicative senescence, fusion of dysfunctional telomeres can drive genome instability and oncogenic genomic rearrangements. Therefore, it is important to define the regulatory pathways that guide these opposing effects. Recent work has shown that the...

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Identifiers

PMID: 25751002
DOI: 10.1080/15548627.2015.1017189
PMCID: PMC4502814

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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