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Article

Autophagy-independent senescence and genome instability driven by targeted telomere dysfunction.

Autophagy - 1 Jan 2015

Mar Florie A, Debnath Jayanta, Stohr Bradley A

Abstract excerpt

Telomere dysfunction plays a complex role in tumorigenesis. While dysfunctional telomeres can block the proliferation of incipient cancer clones by inducing replicative senescence, fusion of dysfunctional telomeres can drive genome instability and oncogenic genomic rearrangements. Therefore, it i...

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Identifiers

PMID: 25751002
DOI: 10.1080/15548627.2015.1017189
PMCID: PMC4502814

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25751002-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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