Article
Deconvoluting the composition of low-frequency hepatitis C viral quasispecies: comparison of genotypes and NS3 resistance-associated variants between HCV/HIV coinfected hemophiliacs and HCV monoinfected patients in Japan.
PloS one - 1 Jan 2015
Ogishi Masato, Yotsuyanagi Hiroshi, Tsutsumi Takeya, Gatanaga Hiroyuki, Ode Hirotaka, Sugiura Wataru, Moriya Kyoji, Oka Shinichi, Kimura Satoshi, Koike Kazuhiko
Abstract excerpt
Pre-existing low-frequency resistance-associated variants (RAVs) may jeopardize successful sustained virological responses (SVR) to HCV treatment with direct-acting antivirals (DAAs). However, the potential impact of low-frequency (∼0.1%) mutations, concatenated mutations (haplotypes), and their association with genotypes (Gts) on the treatment outcome has not yet been elucidated, most probably owing to the...
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