Developmental susceptibility to PFOS toxicity in Drosophila shows genetic variation in toxicodynamics and rescue via enhanced muscle mitochondrial function.

Abstract excerpt

Per- and polyfluoroalkyl substances (PFAS) are ubiquitous environmental contaminants causing widespread concern for developmental toxicity in humans. PFAS can cause adverse developmental outcomes, yet factors determining PFAS susceptibility remain poorly understood. Whether PFAS resistance reflects generalized stress tolerance shared with other toxicants has not been explored. To address this, we assayed a panel...

Topics

• Animals
• Fluorocarbons
• Alkanesulfonic Acids
• Drosophila melanogaster
• Mitochondria, Muscle
• Larva